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Contact information

Email
patrik.rorsman@hmc.ox.ac.uk

Telephone
+44 (0)1865 857348

PA
Amara Jandu
amara.jandu@ocdem.ox.ac.uk

Colleges

Harris Manchester College

Patrik Rorsman

BM, PhD, FRS, FMedSci

Professor of Diabetic Medicine

Diabetes, Insulin secretion

We study the normal regulation of plasma glucose and how it becomes disrupted in diabetes. Our work focuses on the cells that secrete the plasma glucose-regulating hormones glucagon (that increases plasma glucose) and insulin (that lowers plasma glucose). In diabetes, insulin secretion is reduced and glucagon secretion increased. The aim of our work is to establish why these disturbances develop and if they can be corrected pharmacologically.

Recent publications

Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.

Saponaro C. et al, (2026), Diabetologia

Partial restoration of counterregulatory circulating glucagon by dapagliflozin and low-dose glibenclamide in men with type 1 diabetes: in vitro studies and randomised clinical crossover trial.

Gao R. et al, (2026), EBioMedicine, 128

Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control.

Gao R. et al, (2026), Nature metabolism, 8, 159 - 176

Stephen Ashcroft, 27 January 1942-28 November 2025 IN MEMORIAM

Ashcroft F. et al, (2026), DIABETOLOGIA

Metabolic and Paracrine Heterogeneity of Pancreatic Glucagon-Secreting α-Cells.

Dou H. et al, (2025), Diabetes, 74, 2307 - 2321

ORCID

0000-0001-7578-0767