From the dish to humans: A stem cell recipe for success.

Russ HA., Shilleh AH., Sussel L.

Islet transplantation has proven to be an effective treatment for type 1 diabetes (T1D) yet is hampered by the shortage of available tissue. Recently, two reports from a Viacyte multicenter clinical trial demonstrate the feasibility, safety, and potential efficacy of transplanting macro-encapsulated human stem cell-derived pancreatic endoderm cells into patients with T1D, highlighting the promise of a stem cell-based therapeutic approach.

DOI

10.1016/j.cmet.2022.01.002

Type

Journal article

Publication Date

2022-02-01T00:00:00+00:00

Volume

34

Pages

193 - 196

Total pages

3

Addresses

Barbara Davis Center for Diabetes, Department of Pediatrics, University of Colorado Anschutz Medical Campus, 1775 Aurora Court, Aurora, CO 80045, USA.

Keywords

Stem Cells, Endoderm, Humans, Diabetes Mellitus, Type 1, Islets of Langerhans Transplantation, Cell Differentiation

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