Holm Uhlig

Professor of Paediatric Gastroenterology

Director Centre for Human Genetics

The gastrointestinal immune system has evolved to counteract the invasion of pathogens. To allow a strong inflammatory immune response during infection but avoid tissue damage there is a need for effective immune regulation. Defects in immune regulation lead to immunopathology such as inflammatory bowel disease or environmental enteropathy or celiac disease.

About one-fifth of all patients with inflammatory bowel disease present with initial symptoms during childhood and adolescents. In particular in the very young children patients, an underlying immunodeficiency may cause Iinflammatory bowel disease-like symptoms. The analysis of immune deviation in children with inflammatory bowel disease does contribute to the understanding of the complex puzzle of molecular mechanisms involved in IBD.

Recent publications

TTC7A deficiency: A retrospective international study on treatment and outcomes from the Inborn Errors Working Party of EBMT.

Prunotto G. et al, (2026), Journal of human immunity, 2

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Holm Uhlig

Recent publications

TTC7A deficiency: A retrospective international study on treatment and outcomes from the Inborn Errors Working Party of EBMT.

Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.

HLA-DRB1*01:03 in patients with inflammatory bowel disease: a genotype-phenotype association study.

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease.

Targeting SYK to alleviate MDSC-driven immunosuppression and augment anti-PD1 efficacy.